📌Clinical Guide: Torsades de Pointes (TdP) & Long QT Syndrome (LQTS) --- Key Causes 1. Drug-Induced QTc Prolongation: - High-risk agents: Amiodarone, fluoroquinolones, macrolides, SSRIs, antipsychotics, antiemetics. 2. Electrolyte Imbalances: Hypokalemia, hypomagnesemia. 3. Inherited LQTS: LQTS1/2/3 mutations (confirm via genetic testing). Diagnosis - ECG: QTc ≥460 ms (women) / ≥450 ms (men). - Indeterminate Cases: Holter monitor, exercise stress testing. Acute TdP Management 1. Immediate Actio

Should QT-prolonging drugs be prescribed to type 1 diabetic patients? The mechanisms for QT-prolongation during hyperglycaemia are not well understood. As poorly controlled blood glucose levels are common in patients with Type 1 diabetes, it is important to understand how QT-prolonging drugs will act during episodes of hyperglycaemia. The research at the Richmond Research Institute suggests there is an additive effect of hyperglycaemia and medication on the QT-interval. Therefore, caution should

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