Histone deacetylase - Wikipedia
Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH 3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. [2]
Histone Deacetylases (HDACs): Evolution, Specificity, Role in ...
Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences …
Advancements in Hydrazide-Based HDAC Inhibitors: A Review of …
Jul 10, 2025 · Histone deacetylases (HDACs) are crucial enzymes in regulating gene expression by removing acetyl groups from histone proteins. This deacetylation process influences the …
Mechanisms of HDACs in cancer development - Frontiers
Apr 7, 2025 · Histone deacetylases (HDACs) are a class of epigenetic regulators that play pivotal roles in key biological processes such as cell proliferation, differentiation, metabolism, and …
The many roles of histone deacetylases in development and
Mammalian genomes encode eleven proteins of the classical histone deacetylase (HDAC) family. They are numbered HDAC1 to HDAC11 and can be classified into four distinct groups (class I, …
Histone Deacetylase - an overview | ScienceDirect Topics
Histone deacetylases (HDACs) were originally identified as enzymes that catalyze the removal of acetyl moieties from the ε-amino groups of conserved lysine residues in the amino terminal tail …
HDAC Understanding Histone Deacetylases and Their Role in
Histone Deacetylases (HDACs) play a crucial role in regulating gene expression through epigenetic mechanisms. HDACs remove acetyl groups from histone proteins, leading to …
Histone deacetylase (HDAC) 9: versatile biological functions and ...
HDAC9 (histone deacetylase 9) belongs to the class IIa family of histone deacetylases. This enzyme can shuttle freely between the nucleus and cytoplasm and promotes tissue-specific …
Histone deacetylase complexes: Structure, regulation and function
Sep 1, 2024 · Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes with deacetylase function are among the epigenetic corepressor complexes in the …
A short guide to histone deacetylases including recent progress …
Feb 19, 2020 · In this review, current knowledge of HDACs is briefly described with an emphasis on recent progress in research on HDACs, especially on class IIa HDACs. Long eukaryotic …