The USMNT has the top scorer in the rivalry with Landon Donovan's six goals leading the way. Donovan found the back of the net during the USMNT's memorable 2-0 victory over Mexico at the 2002 World Cup and would be a consistent thorn in El Tri's side during their matchups.

The United States will face Mexico in the 2025 CONCACAF Gold Cup Final. Since the tournament's start in 1991, the USMNT has won seven times, and Mexico has won nine. Mexico is the current defending champ,