This paper shows that the common recommendation to use group means when there may be nonindependence among observational units is unnecessary, unduly restrictive, impoverishes the analysis, and limits ...

The critical barrier in interaction analysis for next-generation sequencing (NGS) data is that the traditional pairwise interaction analysis that is suitable for common variants is difficult to apply ...

Gene-set analysis of GWAS data can best be understood as an analysis using genes as data points, carrying out a test of the relationship between a gene set and the genetic associations of genes with a ...

We are developing and using novel methods to create ‘household units of analysis’, and linking these to other sources of data for research into the wider determinants of population health. Researchers ...