The primordial germ cells (PGCs) of a recently metamorphosed juvenile Synaptula hydriformis occur with somatic cells in the germinal epithelium of the gonad. As part of the epithelium, PGCs rest on a ...

We show that atypical PKCι, which plays a critical role in the establishment and maintenance of epithelial cell polarity, is genomically amplified and overexpressed in serous epithelial ovarian ...

Using a molecular cellular compass, individual cells in complex organisms know which way is up or down, in epithelial cells known as apical-basal polarity. Determining the orientation is essential for ...

Epithelial cancers display a loss of growth control, tissue organization and cell polarity. 11,12 In this review, we describe the recent evidence that disrupting the apical–basal polarity machinery ...

Photo Caption: A human melanoma cell exhibits a specific polarity which helps attaching to the endothelial layer of the blood vessel (ezrin stained in orange). After the word “cancer”, perhaps the ...

Scientists have developed a mathematical model showing that two types of cellular asymmetry, or 'polarity', govern the shaping of cells into sheets and tubes, according to an article in eLife. The ...

A gene called Prkci can point cells in the right direction, according to a new study in Developmental Biology. In the study, USC Stem Cell researcher In Kyoung Mah from the laboratory of Francesca ...

Scientists have identified a gene in mice that is necessary for normal brain development and may contribute to the most common form of primary brain tumors in children. Dr. Valeri Vasioukhin and ...