A team at UT Southwestern Medical Center has identified a structural trick that lets viruses translate their genetic code inside human cells, even when that code is riddled with “bad” codons the host ...

Genetic diseases are notoriously challenging to treat, especially when each condition requires a tailored approach. With over 10,000 known genetic disorders, developing individual therapies for each ...

There are different kinds of ribonucleic acids that play essential roles in many aspects of molecular biology, including the creation of proteins from gene sequences in DNA. One type of ribonucleic ...

Transfer RNAs (tRNAs) deliver specific amino acids to ribosomes during translation of messenger RNA into proteins. The abundance of tRNAs can therefore have a profound impact on cell physiology, but ...

During translation, tRNA translocation is a key step triggered by the translocase elongation factor G (EF-G), which inserts into the decoding center (DC) and disrupts the interactions between the tRNA ...

Coronaviruses not only use the machinery of the human cells they infect: they modify them to achieve optimal conditions to ...

A groundbreaking study has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the absence of TRMT10A leads to a reduction in ...

A new advanced, high-throughput sequencing technique should enable scientists to have a firmer grasp on the activity of naturally occurring microbiomes in response to real-world conditions and diet.

Genetic medicine has made huge progress over the past two decades. Gene therapy, gene editing, and mRNA treatments are now approved for a growing number of conditions. These approaches focus on fixing ...

Thus, ArcS is an unprecedented tRNA modification enzyme that can act on a nucleoside as the substrate. With the development of mRNA vaccines for COVID-19, modified nucleosides like pseudouridine and 1 ...

The various identities of cells, whether they are in the brain, heart, kidney, or any other tissue, are defined by the genes they expressed. In basic terms, the genes that are active in a cell are ...