The Witcher 3 incorporates several interesting side quests in every major location in the game. The game's optional quests are not typical fetch quests, but rather in-depth and fulfilling experiences.
Game Rant on MSN
Open-world games that reward you for ignoring the main story
It's okay if you don't hyperfocus on the main missions in these open-world games, because the side quests offer plenty of loot and other bonuses.
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