A variety of mutations in lentiviral vector expression systems have been shown to generate a non-integrating phenotype. We studied a novel 12 base-pair U3-long terminal repeats (LTR) integrase (IN) ...
To design safe clinical trials, it is crucial to better understand and predict gene editing outcomes in preclinical studies. Bence György and collaborators have shown that adeno-associated viruses ...
Foamy virus (FV) vectors are an alternative type of retroviral vector with a large packaging capacity, 16 wide host range, 17 and a complementary DNA genome. 18, 19 FV vectors may be less oncogenic ...
After an investigation in an adverse event, Bluebird Bio announced that it is “very unlikely” that the BB305 lentiviral vector (LVV) caused the case of acute myeloid leukemia (AML) which was reported ...
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