Whole-genome sequencing, positional cloning and comparative genomics mainly depend on the construction of high-quality physical maps. Current physical maps have been developed using agarose gel-based ...
A nationwide team of researchers, funded in part by the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), has produced the first sequence-based map of ...
Many powerful genome editing approaches must create breaks across both strands of the DNA double helix and rely on the cell’s own DNA repair machinery to introduce desired changes in the sequence. If ...
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