DNA replication proceeds through specialised structures known as replication forks, where parental duplex DNA is unwound and copied. The faithful progression and stability of these forks are essential ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

An international collaboration steered by David Cortez, Richard N. Armstrong, Ph.D. Chair for Innovation in Biochemistry, explored how cells tolerate DNA damage and genome instability—and they arrived ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered ...

Reversed DNA replication forks protect against stress to maintain genomic stability and serve as central components to cancer resistance, disease suppression, aging and immunotherapy response ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with ...

Despite the importance of DNA replication, numerous aspects of this process are still poorly understood. One fundamental question is: how do replication forks efficiently progress through chromatin?

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...

In mitosis, DNA replication is initiated through the actions of various multiprotein complexes that recognize the start sites within a chromosome and cause the separation of DNA into two ...