R-loops are three-stranded nucleic acid structures comprising an RNA/DNA hybrid and a displaced single-stranded DNA segment. They arise co-transcriptionally when nascent RNA reanneals to the template ...
CRISPR-Cas effector complexes recognise nucleic acid targets by base pairing with their crRNA which enables easy re-programming of the target specificity in rapidly emerging genome engineering ...
This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...
Recently, the research team led by Wei Li and Chao Liu from Guangzhou Medical University Affiliated Women and Children's Medical Center, in collaboration with Fei Gao’s team from the Institute of ...