Animal development consists of a cascade of tissue differentiation and shape change. Associated mechanical signals regulate tissue differentiation. Here we demonstrate that endogenous mechanical cues ...

In a study of over 50 transcription factors, Tbx6 alone was able to stimulate mesoderm formation in laboratory-grown stem cells, and could cause those stem cells to become cardiovascular or ...

The mechanisms used by embryos to pattern tissues across their axes has fascinated developmental biologists since the founding of embryology. Here, using single-cell technology, we interrogate complex ...

At this stage, known as gastrulation, a flat and featureless sheet of cells folds into a living blueprint for the body, a ...

The development of multicellular organisms is controlled by transcriptional networks. Understanding the role of these networks requires a full understanding of transcriptome regulation during ...

Research from Ph.D. candidate Bohan Chen in the lab of Idse Heemskerk of the Department of Cell and Developmental Biology at the University of Michigan Medical School and their colleagues improves ...

Tsukuba, Japan - Many studies have attempted to identify a single transcription factor that can induce formation of mesoderm, an early layer in embryonic development, without help from other cellular ...