Structured illumination microscopy (SIM) is the most preferable system for live-cell super-resolution imaging. It enables the observation of intricate subcellular dynamics. However, conventional SIM ...

Understanding how living cells grow, respond to stimuli, and change over time is central to modern cell biology and drug discovery. Many traditional imaging approaches rely on fluorescent labels, ...

Mitochondria play an essential role in the life cycle of eukaryotic cells. However, we still don’t know how their ultrastructure, like the cristae of the inner membrane, dynamically evolves to ...

We thank Valerie Klaus for contributing to the analysis of the long-term experiments. We thank Dr. Alexey N. Butkevich and Prof. Dr. Stefan W. Hell (Max Planck Institute for Medical Research, ...

Three-dimensional (3D) imaging is essential for investigating cellular structure and dynamics. Traditional optical methods rely on adhesive or mechanical forces to hold and scan cells, which limit ...

Figure | Working principle of Interferometric Image Scanning Microscopy (iISM). (a) Schematic of the iISM microscope and interferometric PSF detection. (b) iISM with adaptive pixel-reassignment (APR) ...

Deep inside a small, windowless room at the University of California, Berkeley, two microscopes are quietly capturing some of the most detailed views of life ever recorded. Day and night, they collect ...

A robust, image-based neurotoxicity assay helps scientists streamline subcellular neuronal analysis with live-cell dyes and high-throughput automated microscopy. Neuronal cell culture models allow ...

Every time a white blood cell engulfs a bacterium, a neuron extends a projection to connect with a neighboring cell, or when a cancer cell forcefully squeezes through tissue to spread, the cell must ...

Using patient-derived cells and advanced imaging, researchers showed that RPGR mutations disrupt cilia coordination and ...

Peking University, Aug 18, 2025: Professor Xi Peng’s team from the College of Future Technology at Peking University has recently developed a triangle structured illumination microscopy (SIM), which ...