Diabetes. 2006;56(3):594-603. Cellular and morphological characteristics of islets and quantification of cell death (including apoptosis and necrosis). For normoxic and hypoxic conditions, ...

Islets of Langerhans and β-cell isolation constitute routinely used cell models for diabetic research, and refining islet isolation protocols and cell quality assessment is a high priority. Numerous ...

BM stem cells may have regenerative effects on islet function through angiogenesis. Human islets (100 islet equivalent/mL) were cultured alone (control) or co-cultured (experimental group) with whole ...

The currently approved islet-transplant method infuses islets into a vein in the liver. This invasive procedure requires the long-term use of immune-suppressing drugs to prevent islet rejection, ...

When human islets were commingled with human R-VECs, all of the islets embedded themselves in the newly formed vascular network, and the R-VECs formed tiny vessels that surrounded and penetrated the ...

A vascularized organoid model of hormone-secreting cells in the pancreas has been developed, with potential to improve diabetes research and cell-based therapies. “Our results highlight the importance ...

Rare, naturally occurring gene mutations provide important insights into normal human physiology. We report on a young girl with severe neonatal hypoglycemia due to a novel glucokinase mutation (V91L) ...

In culture and after transplantation, the oxygen supply of islets and nutrients depends solely on diffusion. The pO 2 level may be sufficiently high throughout the transplanted islets to maintain cell ...