Nature

Erythropoietin protects against hemorrhagic blood–brain barrier disruption through the effects of aquaporin-4

Erythropoietin (EPO) has protective effects against many neurological diseases, including intracerebral hemorrhage (ICH). Here, we aimed to test EPO’s effects on blood–brain barrier (BBB) disruption ...
Nature

Long-term and stable correction of uremic anemia by intramuscular injection of plasmids containing hypoxia-regulated system of erythropoietin expression

Anemia is a frequent complication of chronic renal failure (CRF). Insufficient production of glycoprotein hormone erythropoietin (Epo) is a main causative factor of uremic anemia. Currently, regular ...
The New England Journal of Medicine

TARGT Gene Therapy Platform for Correction of Anemia in End-Stage Renal Disease

Shown is the monthly plasma concentration of erythropoietin (Panel A) and hemoglobin (Panel B) after TARGT EPO implantation in 9 of the 10 patients (the erythropoietin concentration in Patient 7 ...
Medscape

Darbepoetin Reduces Transfusion Needs in Preterm Infants

Injections of an erythropoiesis-stimulating agent (ESA), particularly darbepoetin alfa (Darbe), may eliminate or reduce the need for red blood cell transfusions in preterm infants, according to an ...
FiercePharma

First Subjects Enrolled in Phase IIa Clinical Trial of EPODURE Biopumps to Treat Anemia in Patients with End-Stage Renal Disease on Dialysis

First Subjects Enrolled in Phase IIa Clinical Trial of EPODURE Biopumps to Treat Anemia in Patients with End-Stage Renal Disease on Dialysis MISGAV, Israel & SAN FRANCISCO--(BUSINESS WIRE)--Jul. 17, ...