DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...

Isolation of mutagen-sensitive Chinese hamster cell lines by replica plating / Małgorzata Z. Zdzienicka -- Complementation assays adapted for DNA repair/deficient keratinocytes / Mathilde Fréchet ... ...

Researchers have discovered how the protein XPD detects severe DNA damage and controls its repair. The XPD protein is a central component of our body's own "DNA repair team," known as nucleotide ...

The Summit supercomputer revealed how damaged strands of DNA are surgically repaired by a molecular pathway called nucleotide excision repair, or NER. NER’s protein components can change shape to ...

Researchers decode repair mechanism during transcription of genetic information. Cockayne syndrome is a severe autosomal recessive disorder caused by defective DNA repair mechanisms. People with the ...

New research sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins ...

Mitochondrial DNA has long been treated as a workhorse record of cellular history, but new research suggests it also hides a subtle and previously overlooked form of damage. By uncovering this cryptic ...