The past decade has witnessed a rapid accumulation of single-cell sequencing data from labs across the world. Since the introduction of the first single-cell RNA sequencing (scRNA-seq) technology in ...

Human pancreatic islets from four male non-diabetic multiorgan donors (Fig. 1b) were isolated at The Nordic Network for Islet Transplantation in Uppsala, Sweden, and were then sent to the Human Tissue ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

Chimeric antigen receptor T cell (CAR-T) therapy is considered one of the landmark achievements of modern medicine. The therapy involves harvesting a patient’s own immune cells, genetically ...

A new single-cell technology is giving scientists their clearest view yet of immune cell behavior-capturing not just genetic intent but real-time activity. By measuring RNA and proteins simultaneously ...

For spatial biology to deliver on its potential, foundational aspects of the spatial analysis workflow need to be executed with precision. Here, Kalins Banerjee and Evan Keller explain the importance ...

Scientists can peer into cells to get a limited view of their activity using microscopes and other tools. However, cells and the molecular events within them are dynamic, and developmental processes, ...

Researchers at University Medical Center Utrecht have uncovered a previously underappreciated mechanism that helps immune cells to respond rapidly to infections. Using advanced long-read RNA ...