Anti-PD-1/PD-L1 immune checkpoint blockade (ICB) therapy has revolutionized clinical cancer treatment, while abnormal PD-L1 or HLA-I expression in patients can significantly impact the therapeutic ...
Signal transduction The cellular process that converts a signal, such as a hormone, growth factor, neurotransmitter, cytokine, mechanical force, or environmental cue, into biochemical changes inside ...
A research team led by Prof. Liu Qingsong at the Institute of Health and Medical Technology, the Hefei Institutes of Physical ...
An international study led by a scientist at the University of Ottawa Faculty of Medicine is opening new frontiers in the ...
Mitochondria are dynamic organelles that are essential for cellular energy generation, metabolic regulation, and signal transduction. Their structural complexity enables adaptive responses to diverse ...
Image Caption: Controversial effects of the STING pathway in colitis development. In colon cancer, the pathway shows a similarly complex profile. Activation of STING can stimulate immune defenses that ...
Which neoadjuvant treatment is best for locally advanced esophageal cancer? a systematic review and network meta-analysis. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This ...
Researchers identified a direct connection between cancer-related inflammation and the loss of motivation characteristic of advanced cancer. In a mouse study, they describe a brain pathway that starts ...
Preclinical research across multiple cancer types now shows that the NAD+ salvage pathway, the same biological mechanism targeted by popular anti-aging supplements like nicotinamide mononucleotide ...
Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.
For most children diagnosed with medulloblastoma, the most common malignant pediatric brain tumor, survival rates are encouraging. But for a subset, remission is not the end of the story. Roughly 30% ...
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