The type I CRISPR protein Cas3 works like Pac-Man, chomping away at a continuous stream of nucleotides with intrinsic activity for introducing targeted large deletions from a few hundred base pairs to ...

Cas3, which shreds where Cas9 snips, has been used to chew up long stretches of DNA. Even better, it has done so with precision, a quality seldom associated powerful shredding tools. Combining ...

Duchenne muscular dystrophy (DMD) is a muscle degeneration disorder caused by mutations affecting the dystrophin gene. Researchers show how a dual CRISPR RNA method restored dystrophin protein ...

Cornell researchers have taken an important step toward harnessing CRISPR gene editing in "targeted, safe and potent" cancer treatment, according to Ailong Ke, professor of chemistry and chemical ...

Researchers at North Carolina-based Locus Biosciences think they have a potential cure for antibiotic resistance using CRISPR’s lesser-known Cas3 enzyme. Most of the interest in CRISPR technology ...

The CRISPR gene-editing system is one of the most important medical breakthroughs of recent years, but that doesn't mean it's perfect. The most common enzyme in use is Cas9, which acts like a pair of ...

ITHACA, N.Y. - A Cornell researcher, who is a leader in developing a new type of gene editing CRISPR system, and colleagues have used the new method for the first time in human cells - a major advance ...

Design by Evelyn Mousigian. Buy this photo. The CRISPR-Cas3 system, the focus of the U-M paper, is much less researched than Cas9. Despite this, Rackham student Mason Myers, one of the lead authors on ...

In a recent study published in Stem Cell Reports, researchers evaluated the use of a dual clustered regularly interspaced short palindromic repeats (CRISPR)-Cas3 system for inducing multi-exon ...

CRISPR-Cas3 system mediates DNA cleavage in human cells. (Left) Type I-E CRISPR effector is composed of crRNA, Cas3, and a large Cascade complex, which contains Cas5, Cas6, multiple Cas7, Cas8 ...

Scientists have used a new type of gene editing CRISPR system for the first time in human cells - a major advance in the field. A Cornell researcher, who is a leader in developing a new type of gene ...