A microscope picture of human bone cells (U2OS) showing the localization of a lipid (phosphatidylethanolamine). The lipid is visible in orange, the cell membrane in purple, and endosomes in white.

Bone health relies on a balance between osteoblasts (builders) and osteoclasts (recyclers). Peak bone mass occurs in early adulthood; deficiencies during this window amplify fracture risks later in ...

While research has uncovered many details about how blood cells function within bone marrow, the work of other cells existing in that space has remained a relative mystery. Now, researchers from the ...

We present DeepBone, a multiplex imaging approach that enables spatial mapping of human bone marrow mesenchymal stromal cells in situ. Mesenchymal stromal cell niches were found associated with the ...

Bone tissue is generally resilient and can self-heal, but critical-size defects (CSDs) with complex geometries cannot be repaired without clinical intervention. Customized scaffolds developed using ...

Deep inside our bones, a remarkable process is taking place every second of our lives. Hidden in the soft tissue called bone ...

A hybrid microscope allows scientists to simultaneously image the full 3D orientation and position of an ensemble of molecules, such as labeled proteins inside cells. The microscope combines polarized ...

More than 100 million years ago, a flying reptile called a pterosaur flew over the oceans hunting squid and fish. Much more recently, one of its wing bones was discovered in Brazil, transformed over ...