The San Fransico 49ers travel to the desert to take on the Las Vegas Raiders in Game 2 of the 2025 NFL preseason for both teams. The 49ers are fresh off a 30-9 shellacking by the Denver Broncos in the first preseason game on Aug.

For the 49ers their health has become a greater concern than their preseason performance. They just need to make sure they have enough healthy bodies to keep their key starters out of harm's way. More than 20 players missed their preseason opener vs. the Denver Broncos with injuries, and that number could rise Saturday when they face the Raiders.

The second preseason game versus the Las Vegas Raiders was more entertaining for the San Francisco 49ers than the first. Part of that is because the starters got a bit of action, but it's also because the 49ers had some players stand out.

SANTA CLARA – Nate Sudfeld rejoined the 49ers’ quarterback ranks Tuesday, three years after Brock Purdy beat him out as a rookie for the No. 3 role and an unexpected ascent to the franchise’s throne.

The Raiders lost to the San Francisco 49ers on Saturday at Allegiant Stadium in their second preseason game. Here are six players who helped or hurt their causes.

One of the 49ers' undrafted rookie running backs exited San Francisco's preseason tilt vs. the Raiders via the cart.

Raiders rookie Ashton Jeanty proved he could deliver hits and absorb them at the NFL level. He rushed for a bruising 33 yards and a touchdown on seven carries in Las Vegas’ 22-19 preseason loss to the San Francisco 49ers on Saturday.

Second-year starting right guard Dominick Puni, one of the bright spots of an otherwise grim 2024 season for the 49ers, is expected to miss multiple weeks with a suspected PCL injury. It appears the injury occurred after he was rolled up on during Jake Moody’s first quarter field goal attempt.